Halaal FarmsGhana · Hatchery
Health and Biosecurity

Fowl Pox and Marek's Disease: Two Diseases Vaccines Prevent

Fowl pox spreads by mosquitoes and wounds; Marek's travels in feather dust. What each looks like, when vaccines are given and why Marek's is a hatchery job.

Speckled roosters and hens in a farmyard

Key points

  • Neither fowl pox nor Marek's disease has a cure, so protection depends on one correctly given vaccine and on good hygiene.
  • Fowl pox is carried by mosquitoes and enters through broken skin, which is why outbreaks rise during and after the rains.
  • Pox vaccine is stabbed through the wing web on the farm, and a sample of birds should be checked for a small scab at the site seven to ten days later.
  • Marek's vaccine must be given on the day of hatch because chicks breathe in the virus from feather dust as soon as they are placed.
  • Marek's vaccine needs one to two weeks to protect, so chicks must start in a house cleared of old dust and be brooded away from older birds.

Fowl pox and Marek's disease have almost nothing in common as diseases. One puts scabs on combs and is carried by mosquitoes. The other paralyses legs, grows tumours and travels on the dust from feathers. What they share is this: once signs appear no medicine cures either, and both are prevented by a vaccine given once. The difference that matters to you is who gives it. Pox vaccine goes through the wing web on your own farm when the birds are some weeks old. Marek's vaccine has to go in on the day of hatch, before the chick leaves the hatchery, and if it was missed there is no catching up.

Fowl pox: scabs outside, patches inside

Fowl pox is a slow-moving viral disease of chickens and turkeys of any age. It takes two forms, and both can be present in one flock.

The dry form

Small pale, raised spots appear on the bare skin of the comb, wattles, eyelids and the corners of the beak, and sometimes on the legs or under the wings. Over several days they grow, turn yellowish, then become rough, dark brown scabs that look like warts. After three to four weeks the scabs dry and fall off, leaving a scar. Most birds with the dry form keep eating. The trouble comes when scabs on the eyelids close the eyes, because a bird that cannot see cannot find feed or water. Growth slows, egg production falls, and cockerels meant for sale look unsightly at exactly the wrong time.

The wet form

Here the damage is inside. Raised, yellow-white cheesy patches form on the tongue, the roof of the mouth, the throat and the opening of the windpipe. Birds gasp, swallow with difficulty and stop eating. Deaths are few in the dry form but can be heavy in the wet form, where birds suffocate or starve.

A scratch from fighting is flat, heals within days and does not spread from bird to bird. Pox lesions are raised and warty, take weeks to clear, and week by week more birds show them.

Mosquitoes, wounds and old scabs: how pox moves

The pox virus cannot pass through healthy, unbroken skin. It needs a way in, and it has three.

  • Mosquitoes. A mosquito that feeds on an infected bird can carry the virus for weeks and inject it into every bird it bites afterwards. This is why pox rises during and just after the major and minor rains in the south, and at the end of the wet season in the north. Open-sided houses cannot keep mosquitoes out, so the birds have to be protected from the inside, by vaccination.
  • Broken skin. Pecking injuries, fighting between cocks, sharp wire and mite bites all give the virus an entry. A flock that is pecking is a flock that spreads pox.
  • Dried scabs. Scabs that fall off contain live virus, which survives for months in dust and litter. Birds that breathe or swallow that dust can develop the wet form, and the next flock in an uncleaned house inherits the problem.

Around the farm, the practical work is to remove mosquito breeding sites: old tyres, tins, broken drinkers, blocked gutters, open tanks and any container that holds rainwater for a week. Keep grass and bush cut short around the houses.

Pox vaccination: the wing-web stab

Which birds and when

Any bird that will be kept for months should be vaccinated: layer pullets, breeders, cockerels, local chickens and dual-purpose birds such as Sasso, Kuroiler and Noiler. Turkeys get pox as well, so if you rear turkey poults, ask your vet about protecting them. Broilers sold at six to seven weeks are commonly left out.

As a typical example, pullets are vaccinated once at around six to ten weeks of age, and in any case well before they start to lay. Where mosquitoes are heavy and pox strikes young birds, some programmes vaccinate earlier. Your vet sets the timing, and our article on vaccination schedules for broilers and layers shows where pox sits among the other vaccines.

How it is done

The vaccine is a live virus, supplied dried with a bottle of diluent and a two-pronged applicator. One person holds the bird and spreads a wing so that the wing web, the triangle of thin skin at the front of the wing between the shoulder and the wrist joint, is exposed from underneath. The vaccinator dips the prongs fully into the mixed vaccine and pushes them straight through the web.

  • Part the feathers first. Vaccine wiped off on feathers never reaches the skin.
  • Avoid the visible blood vessels, the muscle and the bone.
  • Dip the applicator again for every bird.
  • Keep the mixed vaccine cool and shaded, and use it within the time stated on the label, commonly an hour or two.
  • Vaccinate every bird in the house on the same day, and only when the flock is healthy.
  • Burn or disinfect the empty vials and leftover vaccine. It is live virus.

Handling technique for all the vaccine routes is covered in our guide to giving poultry vaccines properly.

Checking for takes

Pox is one of the few vaccines where you can see whether the job worked. Seven to ten days after vaccination, catch a sample of birds from different parts of the house, 50 is a sensible number, and look at the wing web. A successful vaccination leaves a small swelling or scab at the puncture site, called a take. It disappears within two or three weeks.

Nearly every bird should show one. If many do not, the vaccine was dead (too warm, too old or used too long after mixing), the technique was poor, or birds were missed. Tell your vet, who will usually advise repeating the vaccination. Record the date, the batch number of the vaccine and the result of the check.

Nursing a flock through a pox outbreak

No drug acts on the virus. The outbreak runs its course, and the aim is to keep birds eating and drinking until the scabs fall.

  • Have a vet confirm it, especially where birds are gasping, because the wet form can be confused with other diseases of the throat and airway.
  • Ask the vet about vaccinating the birds that show no lesions yet. Pox spreads slowly enough that this can protect a large part of the flock.
  • Move birds with closed eyes or blocked throats to a sick pen with feed and water close at hand. Wet mash is easier to swallow than dry.
  • Bathe stuck eyelids with clean, boiled and cooled salty water. Scabs can be dabbed with an iodine solution to dry them. Do not pull scabs off, which makes them bleed and spreads virus.
  • Reduce pecking and fighting. Separate aggressive cocks and correct overcrowding.
  • Give antibiotics only if a vet prescribes them for bacterial infection of the sores.

When the flock is sold, clean the house thoroughly and remove the dust, because fallen scabs keep the virus alive for the next batch.

Marek's disease: paralysis, tumours and slow losses

Marek's disease is caused by a herpesvirus of chickens. It infects white blood cells and turns some of them into tumour cells, which then invade nerves and organs. Signs seldom appear before six weeks of age and are most common between about three and seven months, with the stress of coming into lay a typical trigger. That timing is cruel for a layer farmer: the losses come after months of rearing cost and before many eggs have been sold.

The disease shows itself in several ways.

  • Nerve form. A bird goes lame on one leg, then cannot stand. The classic picture is a bird lying with one leg stretched forward and the other back. A wing may droop or the neck twist. The bird stays alert and wants to eat but cannot reach the feeder, so it wastes away.
  • Tumour form. Tumours grow in the liver, spleen, kidneys, ovary, heart and other organs. From outside you see a pale bird losing weight, with a shrunken comb, that dies after some days. On post-mortem the organs are enlarged with pale, greyish lumps or a general swelling.
  • Eye form. The coloured ring of the eye turns grey and the pupil becomes small or irregular. The bird goes blind.
  • Skin form. The feather follicles are enlarged and lumpy, seen mostly on plucked carcasses.

Marek's does not arrive as a wave of deaths. It is a steady drip: one or two birds a day or a week, for weeks on end. In an unprotected flock the total can reach a third of the birds or more. The virus also weakens the immune system, so affected flocks suffer more from other diseases and respond less well to other vaccines.

Several conditions resemble it. Newcastle disease also causes paralysis and twisted necks, but it hits many birds at once, usually with breathing signs and green droppings. Curled toes and weak legs in chicks of two to four weeks point to a vitamin shortage in the feed, not Marek's. Leg injuries affect single birds and do not progress. Other tumour diseases occur in adult hens without the paralysis. A vet separates these by opening birds and examining the main leg nerves, which are thickened and dull in Marek's disease, and the internal organs.

Feather dust and the race in the first week

The Marek's virus finishes its development in the skin around the feather follicles. It leaves the bird in the tiny flakes of skin and feather that make up much of the dust in a poultry house. Chicks become infected by breathing that dust in.

Three features make the virus hard to avoid. It survives in house dust and litter for many months. An infected bird sheds it for life, whether or not it ever looks sick. And the dust travels: on clothes, hair, egg trays, crates, equipment and the wind between houses. The virus is not passed through the egg, so a chick hatches clean and is infected by its surroundings.

This creates a race. A vaccinated chick needs roughly one to two weeks to build full protection. A chick placed in a house that still holds dust from the last flock, or brooded beside older birds, starts breathing field virus on day one. If the field virus gets established before the vaccine has done its work, the bird can develop Marek's disease in spite of being vaccinated. Younger chicks are also far more easily harmed by the virus than older ones, so every day of delay in exposure helps.

Why Marek's vaccine is a hatchery job

Everything about this vaccine points to the hatchery.

  • Timing. It must be in the bird before exposure. That means the day of hatch, or in large automated hatcheries, injection into the egg three days before hatch. Nothing given at three weeks on the farm can replace it.
  • Route. The vaccine is injected under the skin at the back of the neck, a measured dose for every chick, by trained staff working fast and accurately. A chick that is missed is unprotected for life.
  • Storage. The most effective Marek's vaccines consist of living cells that carry the vaccine virus. They are kept frozen in liquid nitrogen at about minus 196 degrees Celsius, thawed in about a minute in a water bath, mixed gently with a special diluent and used within about an hour. A farm has neither the equipment nor the routine for this. A freeze-dried type that keeps in a refrigerator does exist, but it generally gives weaker protection.

Our article on how a hatchery works, from fertile egg to boxed chick, shows where vaccination fits into hatch day.

Two more facts keep expectations realistic. First, the vaccine prevents tumours and paralysis but does not stop infection. Vaccinated birds can still carry and shed the field virus, so hygiene still matters. Second, layer and breeder chicks are routinely vaccinated against Marek's, while broilers, which are sold long before the usual age of disease, often are not. For dual-purpose and slow-growing birds kept for several months, ask.

Chicks from Halaal Farms Ghana are vaccinated at the hatchery before they leave. When you order, ask exactly which vaccines your batch has had and note it in your flock record. Chicks hatched in small backyard incubators and sold informally have very often had no Marek's vaccine at all, which is one of the hidden costs of a cheap pullet chick.

Chickens and a rooster foraging
Chickens and a rooster foraging.

The farmer's part: protecting vaccinated chicks

The hatchery gives the vaccine. You give it time to work.

  1. Remove the old dust. After each flock take out all litter, then brush and wash roof timbers, mesh, ledges, curtains and equipment before disinfecting. Dust left on a beam is Marek's virus waiting for the next chicks. The full sequence is in our guide to cleaning and disinfecting a poultry house between batches.
  2. Brood chicks away from older birds. Use a separate house, as far from adult stock as your land allows and not downwind of it. A brooding corner inside the layer house is the worst arrangement.
  3. Visit chicks first. Attend to the youngest birds at the start of the day in clean clothes and boots, before going near older flocks.
  4. Keep used materials out. Second-hand egg trays, crates and feeders from other farms carry feather dust.
  5. Avoid extra stress. Chilling, overcrowding, mouldy feed and Gumboro disease all weaken the immune response that the vaccine depends on.
  6. Cull paralysed birds promptly and humanely once a vet has confirmed Marek's. They will not recover and they shed virus heavily.
  7. Keep records. Note the age at which cases start and the weekly number. Share them with your vet and your chick supplier.
Do not rear replacement pullets in the same air space as your laying hens. Older birds are a constant source of Marek's virus, and day-old chicks are at their most vulnerable in the very days before the vaccine has taken effect.

The two diseases side by side

PointFowl poxMarek's disease
How it spreadsMosquitoes, skin wounds, dust from dried scabsFeather and skin dust breathed in
Usual ageAny ageSigns from about 6 weeks, mostly 3 to 7 months
What you seeWarty scabs on comb, wattles and eyelids; cheesy patches in mouth and throatLameness and paralysis, wasting, grey eyes, tumours on post-mortem
Pattern of lossSlow spread over weeks; few deaths unless the wet form is presentA steady trickle of cases over weeks or months
Vaccine givenOn the farm, wing-web stab, typically at 6 to 10 weeksAt the hatchery, injection at day-old or into the egg
Can you check it workedYes, look for takes at 7 to 10 daysNo visible sign; rely on the hatchery's record
TreatmentNone; nursing careNone; cull affected birds
Risk to peopleNoneNone

What to settle before the chicks arrive

Both diseases are decided long before you see a sick bird, so the useful questions come at ordering time. Was Marek's vaccine given at hatch? What else was given, and by which route? Our list of questions to ask a hatchery before you buy chicks covers the rest. Then write the fowl pox date into your own programme with your vet, buy the vaccine from a shop that keeps it refrigerated, and plan who will hold birds on the day.

For layer or dual-purpose chicks, or advice on preparing a brooding house apart from your older stock, call Halaal Farms Ghana on 024 915 1503 or send the order form. The minimum order is one box of 50 chicks, and we deliver to all 16 regions.

Questions farmers ask

Can people catch fowl pox or Marek's disease from chickens?

No. Fowl pox is a bird virus and has nothing to do with human chickenpox, despite the similar name. Marek's disease virus infects chickens and is not known to cause illness in people. Meat and eggs from healthy birds in an affected flock are safe to eat. Sick, wasted or dead birds should not be sold or eaten, as with any disease.

Can I vaccinate my chicks against Marek's at home if the hatchery did not?

Not usefully. The vaccine has to be in the chick before it meets the field virus, which happens within hours of placement in most poultry houses, and it needs a week or two to protect. The most effective vaccines are also stored in liquid nitrogen and injected chick by chick. Buy pullet chicks that were vaccinated on the day of hatch.

Do broilers need fowl pox vaccine?

Usually not. Broilers sold at six to seven weeks leave the farm before pox would normally do much harm, so most programmes leave it out. Birds kept longer, such as layers, cockerels, Sasso, Kuroiler, Noiler, local chickens and turkeys, should be vaccinated. On a farm with a history of pox in young birds, ask your vet whether earlier vaccination is worthwhile.

How long does fowl pox last in a flock?

An individual bird carries scabs for about three to four weeks before they dry and fall off. Because pox spreads slowly from bird to bird, the outbreak in a whole house often runs for six to eight weeks or longer. During that time growth slows and egg production falls. Birds that recover are immune afterwards.

Will a chicken paralysed by Marek's disease recover?

Almost never. The paralysis comes from tumour cells invading the nerves, and it gets worse, not better. The bird cannot reach feed and water, loses weight and is trampled, and all the while it sheds virus in its feather dust. Once a vet has confirmed the cause, affected birds should be culled humanely and disposed of away from the flock.

Written by the Halaal Farms Ghana team. We hatch and import day-old chicks at Opeikuma, Kasoa, and deliver to all 16 regions. This article is general guidance for farmers. For diagnosis and treatment of sick birds, speak to a vet or your district veterinary office.

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